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Understanding heart valve regurgitation

Mitral and tricuspid valve regurgitation are serious heart problems that can affect your quality of life

Elderly Couple smiling Eating Cake
Elderly Couple smiling Eating Cake
Elderly Couple smiling Eating Cake

How do heart valves work?

Areas of the heart
Areas of the heart
Areas of the heart
Your mitral valve separates the two chambers on the left side of your heart (right side of the image), with your tricuspid valve separating the chambers on the right side of your heart (left side of the image).

As your heart pumps blood throughout your body, four valves open and close to help blood flow at the right time and in the correct direction. Blood flows from your body to the right side of your heart – through the top right chamber, tricuspid valve and bottom right chamber.

It passes through the lungs to receive oxygen before passing through the left side of the heart – through the top left chamber, mitral valve and bottom left chamber – and flowing out into the body.1

Areas of the heart
Areas of the heart
Areas of the heart
Your mitral valve separates the two chambers on the left side of your heart (right side of the image), with your tricuspid valve separating the chambers on the right side of your heart (left side of the image).

What is mitral regurgitation?


Mitral regurgitation (MR) is a condition in which the mitral valve doesn’t close properly, causing blood to leak back through the valve.1,2

Because this leak can reduce overall blood flow, the heart must work harder to get enough blood to the rest of the body. Mitral regurgitation can worsen over time, and you may not develop symptoms until the condition is severe.3

With mitral regurgitation, you may notice symptoms that affect your quality of life:

  • Shortness of breath
  • Fatigue
  • Heart palpitations
  • Swelling in your feet, ankles or abdomen3

What is tricuspid regurgitation?

Healthy heart vs heart with tricuspid regurgitation
Healthy heart vs heart with tricuspid regurgitation
Healthy heart vs heart with tricuspid regurgitation

Tricuspid regurgitation (TR) is a condition in which the tricuspid valve doesn’t close properly, causing blood to leak back through the valve.1,4

Because this leak can reduce overall blood flow, the heart must work harder to get enough blood to the rest of the body. Tricuspid regurgitation can worsen over time, and you may not develop symptoms until the condition is severe.4

With tricuspid regurgitation, you may notice symptoms that affect your quality of life:

  • Shortness of breath
  • Fatigue
  • Abnormal heart rhythms
  • Swelling in your abdomen, legs or neck veins4

How it’s treated

The PASCAL implant, pictured here in the mitral valve
The PASCAL implant, pictured here in the mitral valve
The PASCAL implant, pictured here in the mitral valve
The PASCAL implant, pictured here in the mitral valve

One treatment option for mitral and tricuspid valve regurgitation is called transcatheter valve repair. Your specialized care team may consider this treatment option if you have severe mitral or tricuspid regurgitation but can’t undergo mitral or tricuspid valve surgery.

Transcatheter mitral valve repair (TMVr) and transcatheter tricuspid valve repair (TTVr) are catheter-based procedures to repair leaking valves.

This option is different from traditional heart surgery, in which the surgeon cuts through the chest wall and then the heart to access the valve. Instead, TMVr and TTVr involve implanting a device through a small cut near your groin using the PASCAL Precision system.

The PASCAL implant, pictured here in the mitral valve
The PASCAL implant, pictured here in the mitral valve
The PASCAL implant, pictured here in the mitral valve
The PASCAL implant, pictured here in the mitral valve

Dorothy's PASCAL
system story

Now I travel all over the country to see my family, and it’s very important to me that I see them, that I be a part of their lives. All of this is possible for me because I feel better.

-

Dorothy, PASCAL Precision system patient



Frequently asked questions

References

  1. heart.org [Internet]. Dallas: American Heart Association; c2023 [cited 2021 Sept 1] Available from: https://www.heart.org/en/health-topics/heart-valve-problems-and-disease/about-heart-valves/heart-valves-and-circulation.
  2. Coleman W, et al. Diagnosing and managing mitral regurgitation. JAAPA. 2017 Jun;30(6):11-14.
  3. Mitral Valve Regurgitation [Internet]. Cedars-Sinai; 2022 [cited 2023 Feb 22]. Available from: https://www.cedars-sinai.org/health-library/diseases-and-conditions/m/mitral-valve-regurgitation.html.
  4. Tricuspid Valve Regurgitation [Internet]. University of Pennsylvania; 2023 [cited 2023 Feb 22]. Available from: https://www.pennmedicine.org/for-patients-and-visitors/patient-information/conditions-treated-a-to-z/tricuspid-regurgitation.
  5. Kodali S, et al. 1-Year outcomes of transcatheter tricuspid valve repair. J Am Coll Cardiol. 2023 May 9;81(18):1766-1776. doi: 10.1016/j.jacc.2023.02.049.
  6. Szerlip M, et al. 2-Year Outcomes for Transcatheter Repair in Patients With Mitral Regurgitation From the CLASP Study. JACC Cardiovasc Interv. 2021 Jul 26;14(14):1538-1548. Erratum in: JACC Cardiovasc Interv. 2022 Jul 11;15(13):1395.
  7. Lim DS, et al. Randomized comparison of transcatheter edge-to-edge repair for degenerative mitral regurgitation in prohibitive surgical risk patients. J Am Coll Cardiol Intv. 2022;15:2523-36.
  8. Edwards Lifesciences. Edwards PASCAL Precision Transcatheter Valve Repair System. Instructions for Use. Available at: https://www.accessdata.fda.gov/cdrh_docs/pdf22/P220003D.pdf [Accessed 27 April 2023].

Medical device for professional use.

For a listing of indications, contraindications, precautions, warnings, and potential adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).

Edwards, Edwards Lifesciences, the stylized E logo, CLASP, Edwards PASCAL, Edwards PASCAL Precision, PASCAL, and PASCAL Precision are trademarks or service marks of Edwards Lifesciences Corporation. All other trademarks are the property of their respective owners.

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